Pharmacokinetics describes the absorption, distribution, metabolism, and excretion of a particular substance in the organism it is administered to.

We have been involved in the characterization of the pharmacokinetics of a number of  medications. We have for instance, in collaboration with the Department of Respiratory Diseases and Allergy, Aarhus University Hospital, determined the pharmacokinetics of voriconazol administered by different routes, and in collaboration with the Department of Endocrinology, Aarhus University Hospital, the pharmacokinetics of various insulin formulations and growth hormone formulations.

Current projects include a collaboration with the Neurointensive Unit, Aarhus University Hospital and the Department of Forensic Medicine, Aarhus University, characterizing the pharmacokinetics of sedatives in critically ill patients with neurological diseases. The aim of the project is to determine why a subgroup of patients require particularly large doses to obtain adequate sedation. Furthermore, we are, in collaboration with the Department of Renal Medicine, Aarhus University Hospital and the Department of Forensic Medicine, Aarhus University, characterizing the pharmacokinetics of tetrahydrocannabinol and cannabidiol in patients with decreased renal function, as well as patients with neuropathic pain and spasticity secondary to multiple sclerosis or spinal cord injury. The latter is part of a nationwide project involving neurology departments and multiple sclerosis clinics, and is additionally considering the efficacy and safety of treatment with medical cannabis.      

Voriconazole Concentrations in Plasma and Epithelial Lining Fluid after Inhalation and Oral Treatment. Andersen CU, Sønderskov LD, Bendstrup E, Voldby N, Cass L, Ayrton J, Hilberg O. Basic Clin Pharmacol Toxicol. 2017 Nov;121(5):430-434.

Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans. Sundelin E, Gormsen LC, Jensen JB, Vendelbo MH, Jakobsen S, Munk OL, Christensen M, Brøsen K, Frøkiaer J, Jessen N. Clin Pharmacol Ther. 2017 Nov;102(5):841-848.

In Vivo Imaging of Human 11C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses. Gormsen LC, Sundelin EI, Jensen JB, Vendelbo MH, Jakobsen S, Munk OL, Hougaard Christensen MM, Brøsen K, Frøkiær J, Jessen N. J Nucl Med. 2016 Dec;57(12):1920-1926.

Translational mixed-effects PKPD modelling of recombinant human growth hormone - from hypophysectomized rat to patients. Thorsted A, Thygesen P, Agersø H, Laursen T, Kreilgaard M. Br J Pharmacol. 2016 Jun;173(11):1742-55.

[11C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency. Jensen JB, Sundelin EI, Jakobsen S, Gormsen LC, Munk OL, Frøkiær J, Jessen N. Diabetes. 2016 Jun;65(6):1724-30.

Impact of moderate interval exercise versus supine rest on the pharmacokinetics and pharmacodynamic profiles of subcutaneously administered growth hormone in adult growth hormone deficient patients. Janukonytė J, Parkner T, Lauritzen T, Christiansen JS, Frystyk J, Pedersen HS, Laursen T. Growth Horm IGF Res. 2014 Oct;24(5):198-204.